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Topicals for hair health are in demand from indie beauty brand.
August 4, 2025
By: Melissa Meisel
Indie brand DefenAge 150K Hair Follicle Serum targets hair stress, aging and more.
This multi-tasking, lightweight serum uses breakthrough Defensin molecules to support follicle health, reduce shedding and enhance hair vitality.
“Hair loss in women can profoundly affect emotional well-being, self-esteem, and confidence,” explains facial plastic surgeon Dr. Gregory Keller. “The Defensin technology in DefenAge’s serum helps stimulate new hair growth even in compromised follicles, making it a natural and effective alternative to invasive treatments.”
And with fewer Americans opting for expensive, surgical transplants, experts say high-performance topicals are on the rise.
“Patients want effective, science-backed non-surgical options to regenerate hair,” says Dr. Natalie Curcio, dermatologist and hair restoration expert. “DefenAge’s 150K Serum is one of my go-to recommendations! It renews volume, improves scalp health and revives hair texture in a way patients can really see and feel.”
In a clinical study, users saw a 64% decrease in shedding after two months, with a boost in active hair growth from 25% to 85% in three months.
“That kind of shift is incredibly empowering,” adds Dr. Vivian Bucay. “Another benefit that patients appreciate with this product is that it is a true multi-tasker. It can be used effectively for treating the beard area, thinning eyebrows and helps to rejuvenate the scalp and skin under the hair. It is lightweight, gentle on the scalp and hair, non-irritating even for patients who are sensitive and easy to apply.”
The beauty brand powered by Defensin molecules celebrates its 10-year anniversary. It marks a decade of scientific innovation, patient-first skincare and exponential business growth, according to company executives.
Since its 2015 launch, DefenAge redefined anti-aging with its proprietary Defensin technology, which is backed by over 30 clinical studies. Used and endorsed by leading skincare experts, the brand’s formulas activate dormant skin cells to visibly reverse signs of aging without irritation, setting a new standard in regenerative skincare, said the indie company.
In addition to scientific breakthroughs, the brand has experienced rapid business growth. DefenAge has been honored as one of Inc. 5000’s fastest-growing private companies and was named a Most Innovative Company by Fast Company.
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