The Research Institute for Fragrance Materials (RIFM) is requesting concentration data on 198 fragrance ingredients. The deadline is December 20, 2024.

The RIFM Safety Assessment evaluation process focuses on individual fragrance materials, and the process more rapidly incorporates advances in in vitro and in silico methodologies. This focus allows RIFM to take advantage of advances in the science of safety evaluations and meet the increasingly stringent requirements from regulatory bodies and the increased expectations of fragrance users.

Exposure data are essential for completing a safety assessment for all endpoints, notes the Institute. The Creme RIFM Aggregate Exposure Model is a probabilistic aggregate exposure model to calculate total systemic exposure, with distributions used to model various parameters. This model enables the measurement of real-life consumer exposure to a fragrance material. RIFM has published four publications on the model in the peer-reviewed journal Regulatory Toxicology and Pharmacology.

This Excel spreadsheet lists the materials in this 46th concentration survey. The file contains two worksheets. The first contains the 198 fragrance materials included in this survey.

The Creme Global portal link below provides information on registration for transferring survey data and on completing the survey here.

Once registration is complete, the responder can copy data to the online Excel-style spreadsheet and submit responses for each fragrance ingredient. Each organization has a separate data submission site. A companion website guides users through the new online data portal here.