RIFM Initiates Request for Concentration Data on 110 Fragrance Ingredients

The Research Institute for Fragrance Materials (RIFM) has initiated a request for concentration data on 110 fragrance ingredients.

Its Safety Assessment evaluation process focuses on individual fragrance materials, and the process incorporates advances in in vitro and in silico methodologies. This focus allows RIFM to take advantage of advances in the science of safety evaluations and meet the increasingly stringent requirements from regulatory bodies and the increased expectations of fragrance users.

Exposure data are essential for completing a safety assessment for all endpoints. The Creme RIFM Aggregate Exposure Model is a probabilistic aggregate exposure model to calculate total systemic exposure, with distributions used to model various parameters. This model enables the measurement of real-life consumer exposure to a fragrance material. RIFM has published four publications on the model in the peer-reviewed journal Regulatory Toxicology and Pharmacology (look here.)

A spreadsheet lists the materials in this 52nd concentration survey. The Excel file contains two worksheets. The first worksheet contains the 110 fragrance materials included in this survey. See the spreadsheet here.

RIFM asks the survey be complete by May 4, 2026.

This Creme Global portal link will provide information on registration for transferring survey data and on completing the survey: Once registration is complete, the responder can copy data to the online Excel-style spreadsheet and submit responses for each fragrance ingredient. Each organization has a separate data submission site.

A companion website will guide you through the new online data portal here.