Elm Biosciences, a clinically advanced skincare brand co-founded by Martha Stewart and board-certified dermatologist Dr. Dhaval Bhanusali, has launched a new night cream designed to deliver visible renewal with a focus on tolerability, says the brand.

A3O Elemental Night Cream is a restorative overnight treatment designed to visibly smooth fine lines, improve firmness and deeply hydrate skin while supporting long-term skin health.

“We created Elm to answer a personal need for high-performance skincare unlike any other, and with each new launch, we are committed to elevating the standard of excellence to ensure we are offering the best ingredients and formulations. Our new Night Cream is no exception,” said Stewart in a news release. “I’ve been using it consistently and have been loving the results. My skin is noticeably [firmer] and without any dryness issues that caused me not to use retinoids in the past.”

Lab To Patient Approach

Formulated with a fourth-generation retinoid system and Elm’s patent-pending A3O Proprietary Complex, the Night Cream was developed in collaboration with Elm’s advisory board of more than 350 dermatologists, scientists, and medical researchers. The formula reflects the brand’s lab-to-patient approach — translating emerging clinical science into real-world skincare solutions.

“The combination of the A3O Complex and Trifarotenyl Caprylate, based on a scientific foundation of ingredient science and clinical evidence, marks an incredible milestone in retinoid formulations for non-prescription skincare,” said Dr. Raja Sivamani, integrative and board-certified dermatologist, clinical investigator and longevity scientist.

AO3 Elemental Night Cream uses a unique retinoid system that is more targeted, gentler and designed for nightly use.

“Traditional retinoids can be difficult for many patients to tolerate. Our mission with Elm was always to bring innovative solutions to modern problems,” said Dr. Dhaval Bhanusali, co-founder, board-certified dermatologist, laser surgeon and biotech entrepreneur. “We believe that this molecule, combined with our A3O Proprietary Complex will redefine the expectations for night creams moving forward. The formula delivers visible renewal while supporting the skin barrier, helping restore moisture, smooth texture, and enhance radiance — without compromising comfort.”

Advanced Retinoid Complex

At the core of the formula is Elm’s A3O-RXTM Complex, an advanced retinoid complex combining A3O Proprietary Complex with Ectoin and Trifarotenyl Caprylate, a sophisticated blend of retinoid alternatives that help visibly improve texture, clarity and tone while remaining gentle enough for nightly use. This thoughtfully designed approach delivers noticeable improvement without the irritation, peeling or downtime typically associated with traditional retinol products.

Campaign with Helena Christensen

Through its partnership with Helena, Elm has partnered with legendary Danish supermodel Helena Christensen as the brand continues to spotlight women who embody confidence and vitality at every stage of life, celebrating a modern vision of aging that prioritizes longevity, self-care, and personal success.

“Helena is one of the great beauties of the modeling industry,” said Stewart. “I first met her in St. Barths when she was first posing for Patrick Demarchelier, and I was sailing by! She continues to be awe-inspiring and is aging gracefully in every way.”

A3O Elemental Night Cream retails for $165 at ElmBiosciences.com.