In partnership with the Department of Internal Medicine at the University of Texas, Sytheon recently published a study on Synoxyl AZ (acetyl zingerone) (AZ).

 

The review article concisely summarizes the multiple properties and pathways that AZ can employ to modulate the damaging effects of reactive oxygen species (ROS) that accumulate over the span of life and are now recognized to play major roles in the onset of aging and cancer development within the skin by: managing the overproduction of ROS as an antioxidant, physical quencher and selective chelator that occurs upon exposure to environmental stressors, notably the sun and aerial pollution; fortifying protection against the type of ongoing DNA damage that continues to occur for hours after sun exposure ends and that correlates with cancer development, with special implications for melanoma; modulating matrisome activity to nurture the integrity of extracellular matrix (ECM) within the dermis; and Stabilizing the popular ascorbic acid precursor tetrahexyldecyl ascorbate (THDC, VitaSynol C) within the dermis by protecting it against degradation by singlet oxygen, which improves THDC’s bioavailability and may blunt its recently discovered pro-inflammatory effects.

 

These multifunctional properties of AZ translate into significant clinical benefits that not only improve the visual appearance of photodamaged skin, but also bolster the skin’s own defenses against sun damage and support the skin’s microbiome in both composition and diversity.