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Novel biotech active DHK quells irritation from other common concerns like sunburn, windburn and dry skin.
September 23, 2025
By: Lianna Albrizio
Associate Editor
Deinde, a “clean” clinical skincare line that targets inflammaging, one of the 14 hallmarks of skin aging, has introduced a new product: Instant-Calming Recovery Gel.
The cooling treatment is clinically proven to provide instant, comforting relief and improve barrier function for sensitive, compromised skin. The brand says the launch marks a significant milestone as it introduces a second novel ingredient, biotech DHK, after debuting its biotech Naringenin last year.
Short for dihydrokaempferol, the antioxidant occurs naturally in prickly pear cactus, which thrives in extremely harsh environments. The brand’s proprietary biotech compound instantly calms and soothes skin to deliver a more even tone complexion while improving skin’s resilience to external aggressors over time. Applied with a unique metal roller tip, Deinde Instant-Calming Recovery Gel’s lightweight formula repairs the skin’s protective barrier while still allowing skin to breathe, facilitating the healing process. It’s ideal for post-procedure care, to reduce the irritating side effects of active ingredients like retinol and helps calm skin from other common concerns like sunburn, windburn and dry skin.
Deinde harnesses the power of biotech-derived ingredients to tackle growing concerns around maintaining skin longevity by supporting skin health at the cellular level. All products are 94% bio-based at minimum, meaning the ingredients are derived from biological sources and are renewable. With 65 scientists behind its parent company, Debut, Deinde benefits from over $100 million in research to unlock higher performing biotech ingredients. Powered by advanced AI that screens over 50 billion molecules based on target claims, the brand says it is ushering in a new way of discovering best-in-class skincare ingredients through its clinically proven formulations.
In addition to its patented, biotech-derived DHK, Deinde’s Instant-Calming Recovery Gel features polysaccharides, a protective, sugar-based molecule, to shield from environmental aggressors like pollution and fine particulates, keeping them from clinging to and irritating skin.
Biotech active squalane is a skin-identical lipid that mimics the skin’s natural moisture, helping to lock in hydration for a softer, smoother and lightweight feel.
When applied after an acid peel, participants using DHK saw a 43% improvement in skin’s tactile smoothness; 40% improvement in skin’s visual smoothness; 52% improvement in skin clarityl 54% improvement in skin radiance; and 81% improvement in overall skin appearance relative to a placebo, based on a clinical study of 30 participants with twice daily application over two weeks.
All components of Deinde products can be recycled and are made with PCR.
Deinde Instant-Calming Recovery Gel retails for $42 on deinde.com.
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