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This Rohto Pharmaceuticals formula contains ascorbic acid, 1,3-propanediol, tocopherol and water.
June 1, 2025
By: TOM BRANNA
Chief Content Officer
US 12,296,038 B2. Yu Kitaoka, Mariko Iwai and Sho Yamashina, all of Osaka, Japan. Assignee: Rohto Pharmaceutical Co. Ltd., Osaka, Japan.
Rohto Pharmaceutical researchers patented a topical composition comprising:
(A) from 1 to 10% by mass of at least one type selected from the group consisting of ascorbic acid and salts of ascorbic acid;
(B) at least 40% by mass of 1,3-propanediol;
(C) at least one type selected from the group consisting of tocopherol, salts of tocopherol, and derivatives of tocopherol; and
(D) water;
wherein the mass ratio of component (D) to component (A) is from 0.5 to 5.0 and the topical composition includes less than 20% by mass of glycol ether.
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