HydroPeptide Launches Nighttime Treatment

HydroPeptide, a leader in peptide science and regenerative skincare, is redefining nighttime skincare with the launch of Collagen ReActivate PM Lifting Treatment Moisturizer + Retinol.

The next-generation formula is designed with collagen-optimizing NIMNI Technology, time-release retinol, and regenerative peptides to visibly lift, firm and restore optimal skin health while asleep. This proprietary blend of amino acids and antioxidants is clinically proven to optimize collagen production. By supporting this process in three key ways—strengthening and enhancing the skin’s structural integrity, feeding cells the nutrients they need to maintain healthy and abundant collagen, and signaling the skin to increase collagen production—NIMNI Technology is shown to increase collagen synthesis by 200% at 90 hours after application, per the brand.

Time-release retinol (0.25%) enhances skin texture and tone while biomimetic peptides (SYN-TC and Neodermyl) and antioxidants (vitamin C and Ellagi-C) work synergistically to improve firmness, reduce the look of fine lines and brighten skin.

“Collagen ReActivate PM is a culmination of everything we stand for,” says Annette Rubin, CEO of HydroPeptide. “This formulation reflects decades of scientific discovery, our unwavering dedication to high-performing peptides, and our belief that clinical skincare should feel as incredible as it performs. More than a mere moisturizer, this is a next-generation solution designed to support skin regeneration during the body’s most crucial restorative period.”

Skin Health at the Cellular Level

The result of over two decades of clinical research, Collagen ReActivate PM was developed in collaboration with Dr. Marcel Nimni, a leader in the discovery of Type II collagen. The launch represents a “major advancement” in the company’s mission to support skin health at the cellular level and underscores its continued commitment to ingredient integrity and clinical efficacy.

Clinical Results

According to a study published in the Journal of Drugs in Dermatology, 91% saw fewer lines and wrinkles and improved texture; and seven key signs of aging were visibly reduced, including wrinkles, skin sagging and uneven skin tone.

Like all HydroPeptide products, Collagen ReActivate PM is free of parabens, phthalates, sulfates and genotoxins. The formula is vegan, gluten-free, not tested on animals and has a skin-healthy pH of 6.9.